Il 6 Antibody Cell Signaling

Il 6 induces proliferation or differentiation in many cell types including b cells thymocytes and t cells.

Il 6 antibody cell signaling.

Myelomonocytic specific il 6 signaling does not affect immune cell infiltration in imq induced psoriasis. Cell signaling technology s il 6 d3k2n rabbit mab is a rabbit monoclonal antibody clone d3k2n. Il 6 binds to il 6 r alpha triggering il 6 r alpha association with gp130 and gp130 dimerization. This l selectin activation during heat responses was dependent on il 6 trans signaling via the soluble il 6r.

Treatment of murine skin with imq results in a different profile and increased numbers of infiltrating cells in the skin and secondary lymphoid organs 6 9 31. Il 6 in concert with tgf β is important for developing th17 responses. Gp130 homodimerization triggers the jak stat cascade and the shp 2 erk map kinase cascade 1 3 4. Hence anti il6 agents have been sought.

Il 6 binds to il 6rα and through this association induces gp130 homodimerization 1. Il 6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit il 6 r alpha and a signal transducing subunit gp130. Aberrant il 6 signaling contributes to the pathogenesis of autoimmune diseases inflammation and cancers such as prostate cancer and multiple myeloma. Gp130 homodimerization triggers the jak stat cascade and the shp 2 erk map kinase cascade 1 3 4.

As classic il 6 signaling relies on the expression of membrane bound il 6 r alpha it is primarily limited to hepatocytes macrophages neutrophils and resting lymphocytes. Il 6 in concert with tgf β is important for developing th17 responses. Anti interleukin 6 agents are a class of therapeutics interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Gp130 is also a component of the receptors for clc cntf ct 1 il 11 il 27 lif and osm.

Jak inhibitors currently are being tested in models of multiple myeloma. Il 6 binds to il 6rα and through this association induces gp130 homodimerization 1. Stat3 can act as an oncogene and is constitutively active in many tumors. The il 6 d3k2n rabbit mab antibody was generated using hsf il 6 il6 and interleukin 6 as the antigen.

Our in vitro data indicate that endothelial il 6 trans signaling formed an inflammation circuit for robust il 6 il 8 and mcp 1 production and promoted pai 1 production. The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 c resulted in increased leukocyte adhesion to tissue sections which was mediated by l selectin activation in lymphocytes. However il 6 can also activate trans signaling in cells that express gp130 but lack expression of il 6 r alpha. In rheumatoid arthritis they can help patients unresponsive to tnf inhibitors.